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KMID : 1146920180480030225
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Journal of Pharmaceutical Investigation
2018 Volume.48 No. 3 p.225 ~ p.231
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Chiral separation using chiral crown ethers as chiral selectors in chirotechnology
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Adhikari Suraj
Lee Won-Jae
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Abstract
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This article reviews the enantiomer separation using two typical chiral crown ethers as chiral selectors in chirotechnology. The coated chiral crown ether type chiral stationary phase (CSP) derived from bis-(1,1′-binaphthyl)-22-crown-6 and the covalently bonded chiral crown ether type CSP derived from (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) in the term of their suitability and applicability are discussed and compared in chiral HPLC. It was shown that the covalently bonded type CSP using 18-C-6-TA as a chiral selector has been widely applied for resolving various chiral primary amines in chiral HPLC. Furthermore, this article focuses on the enantiomer separation and their applications using (+)- and/or (?)-18-C-6-TA as chiral selectors for capillary electrophoresis as well as a chiral solvating agent for nuclear magnetic resonance spectroscopy.
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KEYWORD
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Chiral crown ether, Chiral selector, Chiral solvating agent, Chiral stationary phase, 18-Crown-6-2, 3, 11, 12-tetracarboxylic acid, Enantiomer separation
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